Applications
Discover more with single cell omics
From single cell transcriptomics to epigenomics and beyond, Scale Bio’s products are enabling the next wave of scientific discoveries. Learn about different applications of single cell -omics and how our products can transform your research.
Your gateway to single cell omics
Single cell analysis unlocks the ability to examine individual cells through multiple biological lenses - from gene expression patterns and epigenetic modifications to protein levels and gene function. These complementary approaches allow scientists to build comprehensive cell atlases, uncover disease mechanisms, track cellular responses to therapeutics, and map the complex regulatory networks that govern cell identity and function.
Single cell transcriptomics
Profiling messenger RNA (mRNA) in individual cells or nuclei enables a powerful view into cell type and function. Use single cell RNA sequencing (scRNA-seq) to unravel tissue heterogeneity, measure response to drugs or other stimuli, compare healthy and disease states, and identify rare or novel cell types.
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- Drug Screening (App note coming soon)
Single cell epigenomics
Single cell epigenetics sheds light on gene regulation by profiling epigenetic modifications such as DNA methylation or chromatin accessibility. DNA methylation is the most studied epigenetic mark and is essential for cellular differentiation by altering binding of proteins to DNA and regulating gene expression. Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) measures open chromatin regions in the genome, which are associated with active promoters and enhancers.
Unlike bulk DNA methylation assays or ATAC-seq, single cell epigenomic methods can help uncover cell-type or -state specific signatures that are obscured when analyzing heterogenous cell populations, such as tissues.
Learn more in our Single cell DNA Methylation eBook
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Featured products
- Single Cell Methylation Kit
- Tagmentation Toolkit: Pre-indexing for high-throughput single cell workflows with 24 unique barcoded transposases. Request Toolkit
Single cell proteomics
Deeply characterize cellular functions and states by profiling proteins at single cell resolution. Unlike CyTOF and flow cytometry methods, there is no upper limit on the number of markers that can be detected simultaneously with next-gen sequencing and oligo-barcoded antibodies.
Use single cell protein profiling to characterize complex tumor or immune cell samples, detect rare cell populations, identify biomarkers, and profile therapy responders/non-responders
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Functional genomics & perturbomics
CRISPR screening of genes or regulatory elements enables the systematic dissection of their function. Deeply characterize the phenotypic effects of a given CRISPR guide by profiling single cell transcriptomic changes, across thousands of perturbations.
Gain insights into gene or regulatory element functions, screen for potential therapeutic targets, uncover disease pathways and mechanisms with single cell CRISPR screening.
Explore research areas
- Pooled CRISPR screening (App note coming soon)
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