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Performed multi-modal single cell and spatial profiling of a multi-region GBM patient cohort to characterize infiltrative GBM cells. This helped reveal how GBM cells hijack neurodevelopmental programs to drive brain infiltration.

Establishes proof-of-principle for an approach where single-cell genomics precisely maps neural substrates governing behavior.

Introducing sciMETv3, a combinatorial indexing-based technique that enables atlas-scale libraries to be produced in a single experiment. Nichols, Ruth V. et al Cell Genomics, Volume 0, Issue 0, 100726

These findings illuminate MYT1L’s role in orchestrating gene expression during neuronal development, providing insights into the molecular underpinnings of MYT1L syndrome. Yen, A., Sarafinovska, S., Chen, X. et al. MYT1L deficiency impairs excitatory neuron trajectory during cortical development. Nat Commun 15, 10308 (2024).