Applications

Discover more with single cell omics

From single cell transcriptomics to epigenomics and beyond, Scale Bio’s products are enabling the next wave of scientific discoveries. Learn about different applications of single cell -omics and how our products can transform your research.

Your gateway to single cell omics

Single cell analysis unlocks the ability to examine individual cells through multiple biological lenses - from gene expression patterns and epigenetic modifications to protein levels and gene function. These complementary approaches allow scientists to build comprehensive cell atlases, uncover disease mechanisms, track cellular responses to therapeutics, and map the complex regulatory networks that govern cell identity and function.

Single cell transcriptomics

Profiling messenger RNA (mRNA) in individual cells or nuclei enables a powerful view into cell type and function. Use single cell RNA sequencing (scRNA-seq) to unravel tissue heterogeneity, measure response to drugs or other stimuli, compare healthy and disease states, and identify rare or novel cell types.

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Cell Atlases

Drug Screening (App note coming soon)

Disease Mechanisms

Cancer biology

Featured products

Single Cell RNA Sequencing Kit

CRISPR Guide Enrichment Kit

Single cell epigenomics

Single cell epigenetics sheds light on gene regulation by profiling epigenetic modifications such as DNA methylation or chromatin accessibility. DNA methylation is the most studied epigenetic mark and is essential for cellular differentiation by altering binding of proteins to DNA and regulating gene expression. Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) measures open chromatin regions in the genome, which are associated with active promoters and enhancers.

Unlike bulk DNA methylation assays or ATAC-seq, single cell epigenomic methods can help uncover cell-type or -state specific signatures that are obscured when analyzing heterogenous cell populations, such as tissues.

Learn more in our Single cell DNA Methylation eBook

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Biomarker discovery

Tumor heterogeneity

Neuronal diversity

Ageing and molecular clocks

Featured products

Single Cell Methylation Kit
Tagmentation Toolkit: Pre-indexing for high-throughput single cell workflows with 24 unique barcoded transposases. Request Toolkit

Single cell proteomics

Deeply characterize cellular functions and states by profiling proteins at single cell resolution. Unlike CyTOF and flow cytometry methods, there is no upper limit on the number of markers that can be detected simultaneously with next-gen sequencing and oligo-barcoded antibodies.

Use single cell protein profiling to characterize complex tumor or immune cell samples, detect rare cell populations, identify biomarkers, and profile therapy responders/non-responders

Featured Products

Single Cell Protein Profiling (Coming soon)

Functional genomics & perturbomics

CRISPR screening of genes or regulatory elements enables the systematic dissection of their function. Deeply characterize the phenotypic effects of a given CRISPR guide by profiling single cell transcriptomic changes, across thousands of perturbations.

Gain insights into gene or regulatory element functions, screen for potential therapeutic targets, uncover disease pathways and mechanisms with single cell CRISPR screening.

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