Performed multi-modal single cell and spatial profiling of a multi-region GBM patient cohort to characterize infiltrative GBM cells. This helped reveal how GBM cells hijack neurodevelopmental programs to drive brain infiltration.

Establishes proof-of-principle for an approach where single-cell genomics precisely maps neural substrates governing behavior.

These findings illuminate MYT1L’s role in orchestrating gene expression during neuronal development, providing insights into the molecular underpinnings of MYT1L syndrome. Yen, A., Sarafinovska, S., Chen, X. et al. MYT1L deficiency impairs excitatory neuron trajectory during cortical development. Nat Commun 15, 10308 (2024).

Most studies of mammalian organogenesis rely on model organisms, and, in particular, the mouse.

DNA methylation is a key epigenetic property that drives gene regulatory programs in development and disease.

High-throughput screens (HTS) are a cornerstone of the pharmaceutical drug discovery pipeline (1, 2)

To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcriptomes of single cells or nuclei.

Single-cell genomics assays have emerged as a dominant platform for interrogating complex biological systems.

Single-cell omics provide insight into cellular heterogeneity and function.