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Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration

By Sheila Clark | May 16, 2025

Performed multi-modal single cell and spatial profiling of a multi-region GBM patient cohort to characterize infiltrative GBM cells. This helped reveal how GBM cells hijack neurodevelopmental programs to drive brain infiltration.

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Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation

By Sheila Clark | March 19, 2025

Establishes proof-of-principle for an approach where single-cell genomics precisely maps neural substrates governing behavior.

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MYT1L deficiency impairs excitatory neuron trajectory during cortical development

By Amy Hamilton | March 8, 2024

These findings illuminate MYT1L’s role in orchestrating gene expression during neuronal development, providing insights into the molecular underpinnings of MYT1L syndrome. Yen, A., Sarafinovska, S., Chen, X. et al. MYT1L deficiency impairs excitatory neuron trajectory during cortical development. Nat Commun 15, 10308 (2024).

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The single cell transcriptional landscape of mammalian organogenesis

By cory | June 15, 2023

Most studies of mammalian organogenesis rely on model organisms, and, in particular, the mouse.

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High-throughput robust single cell DNA methylation profiling with sciMETv2

By cory | May 5, 2023

DNA methylation is a key epigenetic property that drives gene regulatory programs in development and disease.

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Massively multiplex chemical transcriptomics at single cell resolution

By cory | May 5, 2023

High-throughput screens (HTS) are a cornerstone of the pharmaceutical drug discovery pipeline (1, 2)

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Comprehensive single cell transcriptional profiling of a multicellular organism

By cory | May 5, 2023

To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcriptomes of single cells or nuclei.

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High-content single cell combinatorial indexing

By cory | May 5, 2023

Single-cell genomics assays have emerged as a dominant platform for interrogating complex biological systems.

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Ultra-high throughput single cell analysis of proteins and RNAs by split-pool synthesis

By cory | May 5, 2023

Single-cell omics provide insight into cellular heterogeneity and function.

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