Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration
Performed multi-modal single cell and spatial profiling of a multi-region GBM patient cohort to characterize infiltrative GBM cells. This helped reveal how GBM cells hijack neurodevelopmental programs to drive brain infiltration.
Read MoreSingle-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation
Establishes proof-of-principle for an approach where single-cell genomics precisely maps neural substrates governing behavior.
Read MoreMYT1L deficiency impairs excitatory neuron trajectory during cortical development
These findings illuminate MYT1L’s role in orchestrating gene expression during neuronal development, providing insights into the molecular underpinnings of MYT1L syndrome. Yen, A., Sarafinovska, S., Chen, X. et al. MYT1L deficiency impairs excitatory neuron trajectory during cortical development. Nat Commun 15, 10308 (2024).
Read MoreThe single cell transcriptional landscape of mammalian organogenesis
Most studies of mammalian organogenesis rely on model organisms, and, in particular, the mouse.
Read MoreHigh-throughput robust single cell DNA methylation profiling with sciMETv2
DNA methylation is a key epigenetic property that drives gene regulatory programs in development and disease.
Read MoreMassively multiplex chemical transcriptomics at single cell resolution
High-throughput screens (HTS) are a cornerstone of the pharmaceutical drug discovery pipeline (1, 2)
Read MoreComprehensive single cell transcriptional profiling of a multicellular organism
To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcriptomes of single cells or nuclei.
Read MoreHigh-content single cell combinatorial indexing
Single-cell genomics assays have emerged as a dominant platform for interrogating complex biological systems.
Read MoreUltra-high throughput single cell analysis of proteins and RNAs by split-pool synthesis
Single-cell omics provide insight into cellular heterogeneity and function.
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