Learn about quantum barcoding

Transform your single cell research with next-generation Quantum Barcoding technology

Massively parallelized barcoding gets an exponential upgrade with our newest platform, QuantumScale, powered by our innovative Quantum Barcoding technology. Unleash the most powerful single cell technology to go boldly where your experiments take you.

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Quantum Barcoding technology: Revolutionary single cell at any scale

Supercharge your single cell experiments with industry-leading sample throughput while minimizing your time at the bench with the QuantumScale platform. Novel Quantum Barcoding plates and uniquely barcoded beads provide an unprecedented level of single cell barcoding instrument-free and with minimal effort, enabling you to flexibly scale the number of samples, timepoints, conditions, and replicates, with ease. Leave droplet and traditional combinatorial indexing methods behind and join us for the next great leap in single cell.

Watch how it works

Unlike combinatorial indexing strategies that require additional split-and-pool steps for increasing the barcode space and therefore the number of unique cells that can be analyzed, Quantum Barcoding consolidates many levels of barcoding, cutting the amount of hands-on time by over 75%.

From sample to insights: Powerful technology behind a simplified workflow

Cell fixation or ScalePlex

Fix cells or nuclei and store for up to 1 year or process right away.

If running many samples, use our streamlined multiplexing technology, ScalePlex, to reduce wash steps and processing time. ScalePlex pools can be used with the built-in barcodes (96 barcodes) to enable up to 9,216 samples per run.

Reverse transcription indexing

Distribute fixed samples into the first indexing plate (>2,000 cells per well). Each well contains a unique barcode, which is attached to transcripts in each well. All wells are then pooled.

Quantum barcoding

Distribute pooled product into the Quantum Barcode Plate, where each well has tens of thousands of microwells. Oligo-coated barcoded beads are distributed into microwells and cells lysed to add the bead barcode to each transcript. All wells are pooled again.

The simplicity of this approach – allowing beads and cells to settle into the tens of thousands of microwells that are contained within each “macro” well – consolidates many levels of barcoding into one streamlined operation.

PCR indexing

The product is split into sub-libraries and a library index is added via PCR.

Sequencing

Libraries are compatible with a range of sequencing platforms.

Data analysis

Process raw sequencing data using our SeqSuite analysis pipeline to easily perform cell calling and QC. File outputs are compatible with commonly used downstream software tools.

Complete single cell solutions

QuantumScale Single Cell RNA: Single cell transcriptomics at any scale

Scale Bio's novel Quantum Barcoding technology represents a fundamental rethinking of how we approach single cell analysis, greatly expanding the number of cells that can be analyzed with massively parallel barcoding approaches, while simultaneously improving workflow efficiency, for the most user-friendly single cell workflow.

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TotalSeq™ PhenoCyte: High-Parameter Single Cell Proteomics at Scale

Unleash high-parameter cellular phenotyping with trusted reagents and software from BioLegend, powered by Scale Bio’s innovative Quantum Barcoding technology
Simultaneously measure hundreds of proteins for comprehensive profiling, across dozens of samples
Detect rare cell populations as low as 1 in 10,000 cells with highly sensitive reagents and low background
Flexible throughput from 200k to over a million cells for performing small or larger scale studies

Go to BioLegend’s TotalSeq™ PhenoCyte solution page to learn more about this exciting protein application.

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