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Establishes proof-of-principle for an approach where single-cell genomics precisely maps neural substrates governing behavior.

Introducing sciMETv3, a combinatorial indexing-based technique that enables atlas-scale libraries to be produced in a single experiment. Nichols, Ruth V. et al Cell Genomics, Volume 0, Issue 0, 100726

These findings illuminate MYT1L’s role in orchestrating gene expression during neuronal development, providing insights into the molecular underpinnings of MYT1L syndrome. Yen, A., Sarafinovska, S., Chen, X. et al. MYT1L deficiency impairs excitatory neuron trajectory during cortical development. Nat Commun 15, 10308 (2024).

Single cell-omics has transformed our understanding of cellular heterogeneity and cell function.